Wasp Pharmacology

A beewolf wasp
From http://en.wikipedia.org/wiki/File:Wasp_August_2007-12.jpg
Beewolves are solitary wasps that typically prey on bees. The females dig tunnels and then drag their bee prey into the tunnels, where they lay their eggs on the bee. That way, when the larvae hatch, they have a ready source of food. There are several species of beewolves, but one in particular, Philanthus triangulum, loves to prey on honeybees, which makes it a pest for beekeepers.

Scientists from both the Max Planck Institute for Chemical Ecology and the University of Regensburg studied the reproductive process of this species, and they found an amazing thing: the female uses a cocktail of antibiotics to protect her young.1 Where does the female get those antibiotics? From bacteria that she cultures in her antennae!

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Bacterial Batteries?

A schematic of the bacterial flagellum.
Image in the public domain.
The bacterial flagellum has become a symbol of the intelligent design movement, and rightly so. After all, bacteria are commonly recognized as the “simplest” organisms on the planet. Nevertheless, these “simple” organisms can make an amazingly well-designed locomotive system. Well, it turns out that the flagellum isn’t the only example of the amazing things that bacteria can construct. It seems that they can construct batteries as well!

I saw a blurb about this in the March 1, 2010 issue of Chemical and Engineering News, so I went online to find more information. I found this article on Nature News. According to the article, Lars Peter Nielsen of Aarhus University (in Denmark) did some experiments to see how bacteria are able to consume organic compounds and hydrogen sulfide in sediments that have very little oxygen. You see, in order to use these compounds, the bacteria have to oxidize them, which means that have to remove electrons from them. In order to remove electrons from the chemicals they consume, however, the bacteria have to “put” those electrons somewhere else. In most organisms, the electrons go to oxygen molecules. This process, reasonably enough, is called oxidation, and it is the reason you and I breathe. We take in oxygen so that we can oxidize our food, which produces energy for us to live.

It is very easy to understand how most organisms oxidize their food, because most organisms are exposed to a reasonable amount of oxygen in the air they breathe or the water in which they swim. However, there are lots of sediments (on the sea floor, for example) that are low in oxygen underneath the surface of the sediments. Nevertheless, bacteria in those oxygen-poor sediments seem to oxidize organic compounds and hydrogen sulfide just fine. Nielsen wanted to know how they accomplish this feat.

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Young-Earth Creationism Is Good for Science

There is a great article on the Creation Ministries International website called “Why Young-Age Creationism Is Good for Science.” The author (Brent W. Smith) makes some excellent points, so I would like to summarize what he says and then add one thought. You can tell Mr. Smith is a philosopher by how he summarizes his argument:

The basic idea is that [young-age creationists] offer to the current origins science establishment a competing rational viewpoint that will augment fruitful scientific investigation through increased accountability for scientists, introduction of original hypotheses, and general epistemic improvement.

If you don’t know what “epistemic improvement” means, you just need to know that epistemology is the branch of philosophy concerned with the nature and limitations of knowledge. It attempts to understand how we know things, how knowledge is acquired, and what knowledge actually is. Thus, in this case, “epistemic improvement” means an improvement in our understanding of what we can know through scientific inquiry.

Obviously, young-earth creationism will improve the epistemology of science, because it continually argues with the establishment about what we can learn from scientific data. For example, the fact that soft tissue has been found in fossils that are supposedly millions of years old can lead us to make one of (at least) two different conclusions: (1) Soft tissue can be preserved over time periods previously not thought possible or (2) The fossils aren’t really millions of years old. Those who believe in a billions-of-years old earth tend to support option (1), and young-earth scientists tend to support option (2). Each side tends to look for data that support its position.

If it weren’t for young-earth creationists, option (2) would not be considered. Thus, scientists would assume that option (1) is what we can learn from the data, and they would go on their merry way, never wondering if the data could mean something else. Young-earth creationists, however, will collect data to try to support their position, which will at least allow for some evaluation of what we can learn from the fact that soft tissue has been found in these fossils. If option (1) ends up being correct, then at minimum, there has been an evaluation of what this fact tells us rather than just an assumption of what it means. If option (2) ends up being correct, then a long-running mistake in science will be fixed. Either way, science wins!

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The Scientific Consensus: Wrong AGAIN

I am a bit behind in my reading, so just today I saw an incredible article in the February 27th issue of Science News. The article, entitled “From Skin Cells to neurons, with no middle man,” discussed some astonishing experiments in which mouse skin cells were turned directly into neurons.1

Researchers at Stanford University took skin fibroblast cells (cells that make a protein called collagen) from a mouse and used a virus to insert genes that encode certain transcription factors. These transcription factors are proteins that actually help to regulate gene activity. In other words, their job is to turn genes on and off. The idea here is that even though skin cells are specialized, they have the same DNA that any other non-reproductive cells have. Thus, if we could “turn on” the right genes and “turn off” other genes, we could turn one type of cell into another type of cell.

So…the researchers inserted genes for three transcription factors that are present when neurons are just starting to form. It is assumed that these transcription factors activate the genes necessary for a stem cell to become a neuron, and they deactivate the genes that a neuron doesn’t need. The researchers thought that if they forced those transcription factors to appear in a skin cell, the transcription factors would turn on and off the right genes to make the skin cell turn into a neuron. They were right.

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99%? 95%? 87%? 70%? How Similar is the Human Genome to the Chimpanzee Genome?

I recently got an E-MAIL from a student who heard a “university professor” say that the human and chimpanzee DNA are 99% similar. She asked whether or not the professor was correct and, if not, how similar is human DNA to chimpanzee DNA?

Well, the answer to her first question is quite easy. The professor was horribly wrong. The nonsensical idea that human and chimp DNA are 99% similar comes from misinterpreting a 1975 paper by Mary-Claire King and A. C. Wilson. 1 This groundbreaking (for its time) article compared several proteins in chimpanzees to their equivalent proteins in humans.

In case you don’t know, proteins are complex molecules that are composed of many smaller molecules (called amino acids) linked together. The primary structure of a protein is simply the order in which its amino acids link up. King and Wilson showed that in many, many proteins, the difference in the primary structures of chimpanzee and human proteins was about 1%. Since DNA determines the order of amino acids in each protein an organism makes for itself, they made the reasonable inference that for the portions of DNA that code for those proteins humans and chimpanzees are 99% similar.

However, the genes that code for these proteins make up a tiny, tiny fraction of the human or chimp genome, and only SOME of those proteins were studied. Thus, the idea that one can extend that number to the entire genome and say that human and chimp DNA are 99% similar is just absurd.

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Dr. Coyne Won’t Debate

The AP article that tried unsuccessfully to discredit the biology text I co-authored as well as the biology text published by Bob Jones University Press is still causing a bit of a stir. This morning, a radio talk show host name Adam McManus sent an invitation to both me and Prof. Jerry Coyne to be on his show to debate the merits of the article. Of course, I agreed right away, since I have no fear of debating anyone on the creation/evolution issue. After all, the facts are on my side. Why wouldn’t I want to debate them?

Well, Dr. Coyne refused to be on the program with me. Mr. McManus then wrote him back trying to convince him that he should do the debate. Mr. McManus even implied that Dr. Coyne seemed afraid to debate. Dr. Coyne still refused, claiming that it wasn’t fear. He said he would be glad to appear by himself, but not with me, because that would give me an air of legitimacy that he does not want to give me.

I find that attitude very interesting. I am not sure why debating someone gives him or her an air of legitimacy. In fact, I think not debating someone gives him or her an air of legitimacy. After all, if you are willing to publicly debate someone, it generally means you think you have the ability to show that the person’s position is wrong. If you refuse to debate someone, it looks more like you are afraid of that person’s arguments. To me, that makes the person’s case look more legitimate and, in fact, superior to yours.

So….even though it is not going to be nearly as interesting, I will be on by myself on March 24th at 5:00 Central time. Dr. Coyne might be on after me or at some other time. I don’t know. The station is AM 630, KSLR.

What Can a Dead Fish Tell You About the Nature of Science?

I am currently doing an Alaskan tour of six cities in seven days, working with educators in a state-wide, publicly-funded charter school system. Even though it is cold, it is a lot of fun. Alaska is beautiful, and the charter school system is excellent. It is great to see quality education occurring in such a novel way.

Because airplanes are the main way one gets from city to city in Alaska, I have been spending a lot of time sitting in airports, on tarmacs, and occasionally on an airplane that is actually flying. As a result, I have been doing a lot of reading. I came across an interesting article in Science Science News today1, and I think it is a great illustration of something I stress in most of my science books.

For several years now, scientists have been using functional magnetic resonance imaging (fMRI) to observe functioning brains. The main technique involves using a magnetic resonance imaging machine to look for small changes that occur within the blood vessels of a person’s brain. The very reasonable argument proposed is that the more active a neuron is, the more blood it needs. Thus, if the fMRI sees an increase in blood flow to a particular region of the brain, the neurons in that region must be more active. So…a subject is stimulated in some way, and the fMRI looks for increases in blood flow. Any region of the brain that “lights up” must be the region that is responsible for either processing whatever stimulus was provided or producing a response to it.

Several hundred papers have been published discussing the results of all manner of fMRI experiments, and they have made all sorts of definitive conclusions regarding what regions of the brain are responsible for processing various stimuli or producing various responses to those stimuli. Well, Craig Bennett wanted to see how reliable fMRI experiments are, so he decided to do a very simple baseline test. He used fMRI to study the way a dead fish’s brain responds to stimuli.

The results were quite interesting.

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