I recently got an E-MAIL from a student who heard a “university professor” say that the human and chimpanzee DNA are 99% similar. She asked whether or not the professor was correct and, if not, how similar is human DNA to chimpanzee DNA?
Well, the answer to her first question is quite easy. The professor was horribly wrong. The nonsensical idea that human and chimp DNA are 99% similar comes from misinterpreting a 1975 paper by Mary-Claire King and A. C. Wilson. 1 This groundbreaking (for its time) article compared several proteins in chimpanzees to their equivalent proteins in humans.
In case you don’t know, proteins are complex molecules that are composed of many smaller molecules (called amino acids) linked together. The primary structure of a protein is simply the order in which its amino acids link up. King and Wilson showed that in many, many proteins, the difference in the primary structures of chimpanzee and human proteins was about 1%. Since DNA determines the order of amino acids in each protein an organism makes for itself, they made the reasonable inference that for the portions of DNA that code for those proteins humans and chimpanzees are 99% similar.
However, the genes that code for these proteins make up a tiny, tiny fraction of the human or chimp genome, and only SOME of those proteins were studied. Thus, the idea that one can extend that number to the entire genome and say that human and chimp DNA are 99% similar is just absurd.
Continue reading “99%? 95%? 87%? 70%? How Similar is the Human Genome to the Chimpanzee Genome?”