There has been a noticeable rise in allergic diseases (like asthma), especially in industrialized nations.1 Several hypotheses have been suggested to account for this fact, but the one that seems to have the most evidence stacking up in its favor is the hygiene hypothesis. This hypothesis suggests that many children who live in industrialized nations are raised in an environment that is just too clean. Because of this, they are not exposed to infectious agents and parasites that properly “train” their immune system. In addition, they miss out on some of the good bacteria and fungi that would take up residence in their body and support their immune system. As a result, the natural development of the immune system is stunted, and the body doesn’t know how to properly respond to certain foreign agents.
Several studies have shown a relationship between the cleanliness of a child’s environment and the child’s risk of developing an allergic disease. For example, studies have shown that children who grow up in rural settings are less likely to develop allergic diseases than those who grow up in urban settings.2 Even within rural settings, there is a difference. Children who grow up on farms seem to be the most protected against asthma and other allergic diseases.3
While there is a lot of indirect evidence for the hygiene hypothesis, a biological mechanism for why a “dirty” environment helps protect children against allergic diseases has been lacking. A recent study from Europe, however, has changed that.4